The Drug-Induced Respiratory Disease Website

Carfilzomib

Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

Marschall A, Merino JCF, Gravalos TL

Fatal pulmonary toxicity following Carfilzomib administration.

Acute medicine 2021;20;286-289 — 2021 — 286-289

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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