XXXIX.a
XXXIX - Rechallenge
Rechallenge can lead to near-fatal or fatal relapse of AE/ILD
Last update 17/06/2026
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Causative drugs
3
II.d
II. Myocardial dysfunction - Heart failure
II.d Cardiovascular collapse - Cardiogenic shock - Hypotension
X.b
X. Pulmonary edema
X.b Pulmonary edema, noncardiogenic (NCPE)
XXXVI.f
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVIII.m
XXXVIII. Miscellaneous - Varia
XXXVIII.m Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea
XXXIX.a
XXXIX. Rechallenge
XXXIX.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD
XXXIX.b
XXXIX. Rechallenge
XXXIX.b Rechallenge can lead to relapse of AE/ILD
II.a
II. Myocardial dysfunction - Heart failure
II.a Left ventricular dysfunction/failure
VI.a
VI. Cardiomyopathy
VI.a Cardiomyopathy (acute, subacute, chronic)
VII.a
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
XI.a
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XVI.e
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XXIV.a
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV.b
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXXIX.a
XXXIX. Rechallenge
XXXIX.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD
I.a
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I.g
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.g QTc prolongation
II.c
II. Myocardial dysfunction - Heart failure
II.c Heart failure (biventricular, congestive)
VII.a
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
XVI.e
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XXIV.a
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV.b
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.m
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.m Subclinical pulmonary infiltrates/ILD
XXIV.u
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.u Transient pulmonary opacities/infiltrates (TAPO)
XXXIX.a
XXXIX. Rechallenge
XXXIX.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD
XXXIX.e
XXXIX. Rechallenge
XXXIX.e Rechallenge may not lead to relapse of the AE/ILD