The Drug-Induced Respiratory Disease Website

Acetazolamide

Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

García M, Albizua Madariaga I, Sainz-Gil M, Lertxundi U

Acetazolamide-induced pulmonary oedema: A disproportionality analysis from the EudraVigilance database.

British journal of clinical pharmacology 2024 Jul;90;1751-1755 — 2024 Jul — 1751-1755

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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