The Drug-Induced Respiratory Disease Website

Acetazolamide

Cardiovascular collapse - Cardiogenic shock - Hypotension

Pulmonary edema, noncardiogenic (NCPE)

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

Rechallenge can lead to relapse of AE/ILD

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.