The Drug-Induced Respiratory Disease Website

Bosutinib

Massive pleural effusion

Publications

Aslan NA, H?ncal HO, Elver Ö, Erol V, Güler N

Bosutinib-induced massive pleural effusion: Cross-intolerance with all tyrosine kinase inhibitors.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2022 Jul 12;;10781552221114070 — 2022 Jul 12 — 10781552221114070

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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