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Philippe Camus, M.D.

Dijon, France

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XIV.b

XIV - Pleural involvement

Massive pleural effusion

Last update 17/06/2026

Causative drugs

1
Bosutinib
2
XI.a

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XIV.a

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV.b

XIV. Pleural involvement

XIV.b Massive pleural effusion

XXIV.a

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV.b

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV.k

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
Diagnosing DIRD
Identify causative drugs
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