The Drug-Induced Respiratory Disease Website

Dupilumab

Eosinophilic pleural effusion

(Pleural eosinophilie >10%). Peripheral eosinophilia, eosinophilic pleuritis, eosinophilic pneumonia and/or BAL eosinophilia can be present as associated features. See PMID 10424528, 12806236

Publications

Lommatzsch M, Stoll P, Winkler J, Zeise-Wehry D, Tronnier M, Weber MA, Virchow JC

Eosinophilic pleural effusion and stroke with cutaneous vasculitis: Two cases of dupilumab-induced hypereosinophilia.

Allergy 2021 09;76;2920-2923 — 2021 09 — 2920-2923

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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