The Drug-Induced Respiratory Disease Website

Niraparib

Imaging: Ground-glass opacities / GGO shadowing

Can be localized, disseminated or diffuse

Shono M, Murakami K, Ohta M, Nakai H, Matsumura N

Interstitial lung disease caused by niraparib in ovarian cancer patient: a case report and literature review.

Japanese journal of clinical oncology 2023 Dec 18;; — 2023 Dec 18

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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