The Drug-Induced Respiratory Disease Website

Idelalisib

Pulmonary infiltrates

Sometimes not specified otherwise

Ravi SN, Choi IW, Ngapgue EK, Stroiney AG, Miranda CJ

Idelalisib-Induced Pneumonitis in Chronic Lymphocytic Leukemia.

Cureus 2024 May;16;e59541 — 2024 May — e59541

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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