The Drug-Induced Respiratory Disease Website

Idelalisib

Limiting pulmonary toxicity was an issue in clinical trials (PMID 26968534)

Pneumonitis (ILD)

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Pulmonary infiltrates

Cough (lone)

Pneumocystis jiroveci pneumonia

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.