The Drug-Induced Respiratory Disease Website

Mercury fumes/vapor

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

Zambratto J, Gottesman E, Hasan Z, Heuser W, Kuschner CE, Mundanchira G, Spaeth KR, Nogar J

Extracorporeal Membrane Oxygenation in the Treatment of Acute Elemental Mercury Inhalation Toxicity.

Chest 2025 Mar;167;e71-e74 — 2025 Mar — e71-e74

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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