The Drug-Induced Respiratory Disease Website

Etoposide

Imaging: Ground-glass opacities / GGO shadowing

Can be localized, disseminated or diffuse

Cook AV, LeRoy DI, Konja CT

A Breathtaking Case of Chemotherapy-Induced Pneumonitis.

Cureus 2025 Feb;17;e78791 — 2025 Feb — e78791

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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