The Drug-Induced Respiratory Disease Website

Chemotherapy (antineoplastic) - Chemo agents

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Hypersensitivity and infusion reactions. May mimic systemic vasculitis (PMID 30746133). See also under 'Anaphylaxis' (Xf). Hypersensitivity reactions include the rapid development of malaise, cough, dyspnea, wheezing-bronchospasm, cutaneous rash, itching and pruritus. These symptoms may annunciate the onset of anaphylaxis (see Xf) especially if the drug is continued or the patient is inadvertenly rechallenged with the drug. Desensitization can be offered (PMID 26895621), so that patients can receive full treatment courses and need not be switched to an alternative, potentially more toxic or inferior therapy. See PMID 12634903, 12721396, 22149339, 22987983. Skin manifestations at PMID 24820798

Publications

Goksel O, Goksel T, Cok G, Karakus H, Bacakoglu F, Goker E, Uslu R, Erdinc M

Hypersensitivity to chemotherapeutics: a cross sectional study with 35 desensitisations.

International journal of clinical oncology 2015 Apr;20;395-404 — 2015 Apr — 395-404

Cortijo-Cascajares S, Jiménez-Cerezo MJ, Herreros de Tejada A

Review of hypersensitivity reactions to antineoplastic agents.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 2012 May-Jun;36;148-58 — 2012 May-Jun — 148-58

Lee C, Gianos M, Klaustermeyer WB

Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2009 Mar;102;179-87; quiz 187-9, 222 — 2009 Mar — 179-87; quiz 187-9, 222

Shepherd GM

Hypersensitivity reactions to chemotherapeutic drugs.

Clinical reviews in allergy & immunology 2003 Jun;24;253-62 — 2003 Jun — 253-62