The Drug-Induced Respiratory Disease Website

Methotrexate

Pneumonitis (ILD)

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.