The Drug-Induced Respiratory Disease Website

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Risks depends on COX-selectivity. Review and guidelines at PMID 21631520. Studies on selective rechallenge at PMID 21981353 and 23278883

Angioedema (may cause UAO, asphyxia and death)

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.