The Drug-Induced Respiratory Disease Website

Aprotinin

Sales suspended in May of 2008

Cardiovascular collapse - Cardiogenic shock - Hypotension

Pulmonary embolism - Venous thrombosis/thrombo-embolism

Pulmonary vascular microthrombi

Acute lung injury - ARDS

Bronchospasm - Wheezing - Asthma

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.