Philippe Camus, M.D.

Dijon, France

Back

The Drug-Induced Respiratory Disease Website

Valproate (Valproic acid)

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

XII - Pericardial involvement

XII.g

Pleural/pericardial effusion, ANA positive (DI lupus)
XII.n

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XIV - Pleural involvement

XIV.a

Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV.d

Eosinophilic pleural effusion

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m

DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome