The Drug-Induced Respiratory Disease Website

Isopropanol (isopropyl alcohol - IPA)

Cardiovascular collapse - Cardiogenic shock - Hypotension

‘Cardiotoxicity’

Acute lung injury - ARDS

Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

Path: Alveolar hemorrhage

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.