The Drug-Induced Respiratory Disease Website

Methanol (topical/dermal, p.o., systemic)

Can be present in household and hospital hand sanitizers (PMID 29987197, 29987197). Early identification, management and administration of antidote are indicated

II - Myocardial dysfunction - Heart failure

II.e

Acute respiratory or cardiopulmonary failure

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

Acute lung injury - ARDS

XXXVIII - Miscellaneous - Varia

XXXVIII.m

Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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