Philippe Camus, M.D.
Dijon, France
PMID 26077036, 30526332
Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
Evidence level
low
Vascultis (pulmonary, extrathoracic or systemic) - ANCA status unknown or negative
Lymphadenopathy (intrathoracic)
Acute lung injury - ARDS
Pneumonitis (ILD)
probable
Pneumonitis (ILD), acute and/or severe (may cause ARDS)
possible
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
Diffuse alveolar damage (DAD) imaging pattern
Cough (lone)
Imaging: A miliary pattern (diffuse random micronodules)
Imaging: A 'tree-in-bud' pattern
Myasthenia gravis - Myasthenic-like syndrome
Guillain-Barré (or GB-like) syndrome (w/wo ARF)
Multiple organ dysfunction/failure (MODS/MOF)
Upper airway obstruction other than angioedema or hematoma
Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)