Hemotherapy (transfusion/infusion of whole blood, red cells, platelets, or blood products)
Essential reading at PMID 25959215. Transfusion of blood or components (platelets, plasma derivatives, FFP, IVIG, factor IX, cryoprecipitate) may produce among other complications the TRALI syndrome, a leading cause of morbidity and mortality from hemotherapy. A screen for anti-HLA and anti-HNA antibodies (usually from a multiparous donor) must be done in any TRALI case. TRALI needs be separated from transfusion-associated circulatory overload (TACO. See under II h) (Bloodborne infections are not covered here). Review at PMID 23642914. Indentified risk factors to review before deciding transfusion (PMID: 24673344)