The Drug-Induced Respiratory Disease Website

Alectinib

Several cases were described in Japan

Pericardial effusion (w/wo tamponade)

Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

Pneumonitis (ILD)

Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

Pulmonary infiltrates

Subclinical pulmonary infiltrates/ILD

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.