The Drug-Induced Respiratory Disease Website

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l

Cardiac- cardiorespiratory/pulmonary arrest

1

Evidence level

low

X - Pulmonary edema

X.b

Pulmonary edema, noncardiogenic (NCPE)

2

Evidence level

possible

X.d

Fluid retention

2

Evidence level

possible

X.f

Capillary leak syndrome (CLS)

1

Evidence level

low

XII - Pericardial involvement

XII.b

Pericardial effusion (w/wo tamponade)

1

Evidence level

low

XIV - Pleural involvement

XIV.a

Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

1

Evidence level

low

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

1

Evidence level

low

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

Acute lung injury - ARDS

2

Evidence level

possible

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)

2

Evidence level

possible

XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

2

Evidence level

possible

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.q

Tumor lysis syndrome (TLS)

1

Evidence level

low

XXXVIII - Miscellaneous - Varia

XXXVIII.k

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

2

Evidence level

possible