Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Cannabinoids - Cannabinoid receptor agonists (synthetic) (K2, Spice)

a.k.a. Spice, K2 bonsai or other colourful names. Include MDMB-CHMICA. Review: PMID 27610597. See also under PMID 27973993. Such adulterants as warfarin or superwarfarins should be examined (PMID 30104022)

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II - Myocardial dysfunction - Heart failure

II.e

Acute respiratory or cardiopulmonary failure

III - Myocardial ischemia - Coronary artery disease

III.a

Coronary artery disease (acute) - Myocardial ischemia/infarction

X - Pulmonary edema

X.b

Pulmonary edema, noncardiogenic (NCPE)

XIII - Thrombosis - Embolism

XIII.a

Pulmonary embolism - Venous thrombosis/thrombo-embolism
XIII.o

Systemic arterial thrombosis

XV - Chest pain

XV.a

Chest pain (acute or subacute), lone or prominent

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI.h

Coagulopathy
XVI.i

Hemoptysis

XXI - Mediastinal involvement/injury

XXI.c

Pneumomediastinum

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

Acute lung injury - ARDS
XXII.e

Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.d

Acute eosinophilic pneumonia (AEP)
XXIV.k

Pulmonary infiltrates
XXIV.w

Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.k

Multiple organ dysfunction/failure (MODS/MOF)

XXXVIII - Miscellaneous - Varia

XXXVIII.d

Death following exposure or poisoning
XXXVIII.r

Hyperemesis