The Drug-Induced Respiratory Disease Website

Dabrafenib-Trametinib combination (BRAFi)

Pneumonitis (ILD)

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

ILD with a granulomatous component

Granulomatous mediastinal lymphadenopathy

Sarcoid-like granulomatosis (endo-/extrathoracic)

Granulomatosis with polyangiitis (typically +ANCA). Or flare of preexisting GPA

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.