Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Beta-blockers

ß-blocker drugs, especially the noncardioelective ones, are generally contraindicated in patients with asthma. In contrast, the risk-to-benefit ratio may be in favor of cardioselective beta-blockers in patients with COPD, especially those with a history of myocardial infarction (PMID 24277628). See under each specific beta-blocking agent

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l

Cardiac- cardiorespiratory/pulmonary arrest

II - Myocardial dysfunction - Heart failure

II.d

Cardiovascular collapse - Cardiogenic shock - Hypotension

III - Myocardial ischemia - Coronary artery disease

III.c

Coronary vasospasm - Vasospastic angina

X - Pulmonary edema

X.b

Pulmonary edema, noncardiogenic (NCPE)

XI - Pulmonary vasculopathies

XI.f

Worsening of preexisting PHTn

XII - Pericardial involvement

XII.g

Pleural/pericardial effusion, ANA positive (DI lupus)

XIV - Pleural involvement

XIV.a

Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV.h

Pleural thickening - Fibrothorax

XXII - Acute respiratory/cardiorespiratory failure

XXII.e

Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.e

Relapsing or migrating pneumonitis/pneumonia (see also Id)
XXIV.h

Pulmonary fibrosis (may improve but partly following drug discontinuation)
XXIV.j

Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma
XXIX.c

Severe or catastrophic bronchospasm or asthma attack (can be fatal)
XXIX.h

Exacerbation or deterioration of preexisting asthma
XXIX.i

Exacerbation or deterioration of preexisting COPD

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b

Lupus - Lupus syndrome
XXXVI.d

Subclinical ANA positivity
XXXVI.l

Refractoriness to epineprine in case of anaphylaxis

XXXVIII - Miscellaneous - Varia

XXXVIII.d

Death following exposure or poisoning