Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Aspirin (Salicylate-ASA) - Aspirin containing drugs

Aspirin-exacerbated respiratory disease (AERD; PMID 24961377) is a naturally-occurring state where aspirin and NSAIDs can produce acute exacerbations and asthma attacks. Tests to document AERD at PMID 17521312. For induction of AS tolerance see PMID 12532116, 23861151, 24369807, 24468245.

Chronic or excessive intake of aspirin can produce pulmonary edema and ARDS (PMID 9743184, 21297545 , 27531848).

II - Myocardial dysfunction - Heart failure

II.d

Cardiovascular collapse - Cardiogenic shock - Hypotension

III - Myocardial ischemia - Coronary artery disease

III.c

Coronary vasospasm - Vasospastic angina

IV - Heart block (bundle branch-, AV-block)

IV.a

Heart block (bundle branch- or AV-)

X - Pulmonary edema

X.b

Pulmonary edema, noncardiogenic (NCPE)

XIV - Pleural involvement

XIV.e

Hemothorax - Serosanguineous pleural effusion

XV - Chest pain

XV.a

Chest pain (acute or subacute), lone or prominent

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI.h

Coagulopathy
XVI.i

Hemoptysis

XX - Vasculitis

XX.c

Vascultis (pulmonary, extrathoracic or systemic) - ANCA status unknown or negative

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

Acute lung injury - ARDS

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.f

Diffuse alveolar damage (DAD) imaging pattern

XXVIII - Large airway involvement

XXVIII.a

Angioedema (may cause UAO, asphyxia and death)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma
XXIX.c

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXXIII - Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.j

Path: Pulmonary edema

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)