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The Drug-Induced Respiratory Disease Website

XXII.e

XXII - Acute respiratory/cardiorespiratory failure

Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

Last update 17/06/2026

Presentation may range from restrictive lung dysfunction to acute respiratory failure with an increased PaCO2 and respiratory acidosis and blunted ventilatory reponse to hypoxia and/or hypercarbia. Aspiration, brain damage and death can occur (See PMID 25536092). See also under IXi, IXIe, IXa, IXj, IXs.

Causative drugs

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