I.m
I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
Sudden cardiac death
Last update 17/06/2026
Back
The Drug-Induced Respiratory Disease Website
Causative drugs
3
I.m
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.m Sudden cardiac death
V.a
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
VII.a
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
XIV.a
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XV.e
XV. Chest pain
XV.e Pleuritis (can cause chest pain)
XXIV.a
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV.b
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXXVI.b
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.b Lupus - Lupus syndrome
XXXVI.f
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVI.ac
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.ac Antisynthetase antibodies (ASA) - ASA syndrome
I.a
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I.m
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.m Sudden cardiac death
II.a
II. Myocardial dysfunction - Heart failure
II.a Left ventricular dysfunction/failure
II.c
II. Myocardial dysfunction - Heart failure
II.c Heart failure (biventricular, congestive)
II.d
II. Myocardial dysfunction - Heart failure
II.d Cardiovascular collapse - Cardiogenic shock - Hypotension
III.a
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
IV.a
IV. Heart block (bundle branch-, AV-block)
IV.a Heart block (bundle branch- or AV-)
V.a
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
V.e
V. Myocarditis
V.e Necrotizing myocarditis (w/o evidence for CAD)
VI.c
VI. Cardiomyopathy
VI.c Takotsubo (stress) cardiomyopathy
VII.a
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
X.a
X. Pulmonary edema
X.a Pulmonary edema, cardiogenic
XI.a
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XII.b
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XIII.a
XIII. Thrombosis - Embolism
XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism
XIV.a
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV.i
XIV. Pleural involvement
XIV.i Serositis - Polyserositis
XV.e
XV. Chest pain
XV.e Pleuritis (can cause chest pain)
XVI.h
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.h Coagulopathy
XXI.a
XXI. Mediastinal involvement/injury
XXI.a Lymphadenopathy (intrathoracic)
XXII.b
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXIV.a
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV.b
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.d
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.d Acute eosinophilic pneumonia (AEP)
XXIV.e
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.e Relapsing or migrating pneumonitis/pneumonia (see also Id)
XXIV.h
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)
XXIV.i
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis
XXIV.j
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
XXIV.l
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.l Acute fibrinous organizing pneumonia (AFOP)
XXIV.o
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.o Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)
XXIV.q
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.q Delayed ILD, -pneumonitis, -fibrosis
XXIV.v
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.v Radiation recall pneumonitis
XXIV.ab
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.ab Chronic pneumonitis/ILD
XXIV.ac
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.ac Shrinking lung syndrome
XXIX.a
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXIX.i
XXIX. Small airway involvement
XXIX.i Exacerbation or deterioration of preexisting COPD
XXX.h
XXX. Imaging features
XXX.h Imaging: Avid pleural uptake on PET-scan
XXXIII.f
XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)
XXXIII.f Path: Myocardial vasculitis
XXXVI.f
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVI.q
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.q Tumor lysis syndrome (TLS)
XXXVI.v
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.v Temporal arteritis (Horton’s)
I.m
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.m Sudden cardiac death
II.e
II. Myocardial dysfunction - Heart failure
II.e Acute respiratory or cardiopulmonary failure
III.a
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
VI.a
VI. Cardiomyopathy
VI.a Cardiomyopathy (acute, subacute, chronic)
X.b
X. Pulmonary edema
X.b Pulmonary edema, noncardiogenic (NCPE)
XI.a
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XV.a
XV. Chest pain
XV.a Chest pain (acute or subacute), lone or prominent
XVI.e
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XX.c
XX. Vasculitis
XX.c Vascultis (pulmonary, extrathoracic or systemic) - ANCA status unknown or negative
XXII.b
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXIV.b
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIX.a
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXXVI.k
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.k Multiple organ dysfunction/failure (MODS/MOF)
XXXVIII.d
XXXVIII. Miscellaneous - Varia
XXXVIII.d Death following exposure or poisoning
XXXVIII.s
XXXVIII. Miscellaneous - Varia
XXXVIII.s CNS involvement/dysfunction/damage