Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

The spectrum of angiotensin converting enzyme inhibitor-induced problems is huge. Cough and angioedema w/wo UAO are the most typical AE from ACEIs. Upper arway angioedema and closure is the most dreadful one. A few cases were described with ARBs. See under each specific ACEI drug. Icatibant is an effective drug in angioedema cases (PMID: 25646708)

XII - Pericardial involvement

XII.g

Pleural/pericardial effusion, ANA positive (DI lupus)

XIV - Pleural involvement

XIV.a

Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV.d

Eosinophilic pleural effusion

XIX - Angioedema

XIX.b

Visceral angioedema

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXVIII - Large airway involvement

XXVIII.a

Angioedema (may cause UAO, asphyxia and death)
XXVIII.i

Tongue involvement (edema, glossitis, hematoma)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma
XXIX.c

Severe or catastrophic bronchospasm or asthma attack (can be fatal)
XXIX.d

Cough (lone)

XXX - Imaging features

XXX.c

Imaging: Upper/central airway narrowing

XXXI - Eye catchers

XXXI.a

Eye-catcher: Tongue edema

XXXV - Disordered breathing during sleep

XXXV.b

Disordered breathing pattern - Cheynes-Stokes respiration
XXXV.c

Obstructive sleep apnea

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b

Lupus - Lupus syndrome

XXXVIII - Miscellaneous - Varia

XXXVIII.b

Unilateral/Hemilingual (angio)edema
XXXVIII.i

Cough syncope