The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.m Sudden cardiac death

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

V. Myocarditis

V.e Necrotizing myocarditis (w/o evidence for CAD)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.i Serositis - Polyserositis

XV. Chest pain

XV.e Pleuritis (can cause chest pain)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XXI. Mediastinal involvement/injury

XXI.a Lymphadenopathy (intrathoracic)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.e Relapsing or migrating pneumonitis/pneumonia (see also Id)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.l Acute fibrinous organizing pneumonia (AFOP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.o Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.q Delayed ILD, -pneumonitis, -fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.v Radiation recall pneumonitis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ab Chronic pneumonitis/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ac Shrinking lung syndrome

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXX. Imaging features

XXX.h Imaging: Avid pleural uptake on PET-scan

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.f Path: Myocardial vasculitis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.q Tumor lysis syndrome (TLS)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.v Temporal arteritis (Horton’s)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XII. Pericardial involvement

XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXVIII. Large airway involvement

XXVIII.k Rhinosinusitis

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.e Obliterative bronchiolitis (an imaging and/or pathological pattern consistent with)

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXIX. Small airway involvement

XXIX.l Bronchiolitis (a clinical-imaging pattern suggestive of)

XXXII. Esophageal pathology

XXXII.e Esophageal toxicity

XXXII. Esophageal pathology

XXXII.j Esophageal necrosis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.q Tumor lysis syndrome (TLS)