The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.f Pneumothorax

XV. Chest pain

XV.d Chest tightness

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.m BAL: Gross or microscopic bleeding/hemorrhage

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.c Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXVII. Dyspnea, lone

XXVII.a Dyspnea, unexplained otherwise

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXIX. Small airway involvement

XXIX.f Deterioration/exacerbation of preexisting asthma or COPD

XXX. Imaging features

XXX.e Imaging: An area or areas of consolidation

XXX. Imaging features

XXX.f Imaging: Alveolar opacities or haze with a batwing or butterfly distribution

XXX. Imaging features

XXX.l Imaging: Ground-glass opacities / GGO shadowing

XXXI. Eye catchers

XXXI.e Eye catcher: A batwing or butterfly pattern on chest imaging

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.k Path: Alveolar hemorrhage

XXXIV. Infections

XXXIV.b Respiratory tract infection incl. pneumonia

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.p Multisystem/systemic inflammatory response/syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.c Antiphospholipid antibodies w/wo the APL syndrome

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XII. Pericardial involvement

XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XVIII. Aortic involvement

XVIII.c Arterial (aorta, limb) vasoconstriction and/or ischemia, acute

XX. Vasculitis

XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive

XXVIII. Large airway involvement

XXVIII.p Nasal, palatal and/or pharyngeal pathology

XXXI. Eye catchers

XXXI.h Midline destructive lesions

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.s Dual MPO-/PR3-ANCA systemic disease/vasculitis or pseudovasculitis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.t Pneumorenal syndrome (w/wo ANCAs)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.u Pulmonary vasculitis or capillaritis

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

XXXVIII. Miscellaneous - Varia

XXXVIII.q Myopathy-Myositis-Polymyositis

XXXVIII. Miscellaneous - Varia

XXXVIII.y Neutropenia, agranulocytosis (w/wo infection/sepsis)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.j Asystole

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

III. Myocardial ischemia - Coronary artery disease

III.e Coronary artery dissection

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.f Pneumothorax

XIV. Pleural involvement

XIV.l Pneumothorax, bilateral

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.y Exogenous lipoid pneumonia (subacute, acute)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ad Pulmonary alveolar proteinosis (PAP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ae Pneumoconiosis (silicosis, talcosis...)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.af Hypersensitivity pneumonitis pattern

XXIX. Small airway involvement

XXIX.d Cough (lone)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.e Sniffing death - Death from inhalation of compound

XII. Pericardial involvement

XII.c Hemopericardium - Bloody pericardial effusion

XII. Pericardial involvement

XII.e Constrictive pericarditis - Pericardial thickening

XIV. Pleural involvement

XIV.e Hemothorax - Serosanguineous pleural effusion

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.a Hemomediastinum - Mediastinal hematoma

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.b Pulmonary hematoma

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.c Hematoma of/around central airway wall potentially causing UAO

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXXII. Esophageal pathology

XXXII.a Esophageal hematoma (may cause chest pain and/or tracheal compression)