The Drug-Induced Respiratory Disease Website
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.i Hemoptysis
XVIII. Aortic involvement
XVIII.c Arterial (aorta, limb) vasoconstriction and/or ischemia, acute
XX. Vasculitis
XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive
XXVIII. Large airway involvement
XXVIII.p Nasal, palatal and/or pharyngeal pathology
XXXI. Eye catchers
XXXI.h Midline destructive lesions
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.s Dual MPO-/PR3-ANCA systemic disease/vasculitis or pseudovasculitis
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.t Pneumorenal syndrome (w/wo ANCAs)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.u Pulmonary vasculitis or capillaritis
XXXVIII. Miscellaneous - Varia
XXXVIII.d Death following exposure or poisoning
XXXVIII. Miscellaneous - Varia
XXXVIII.q Myopathy-Myositis-Polymyositis
XXXVIII. Miscellaneous - Varia
XXXVIII.y Neutropenia, agranulocytosis (w/wo infection/sepsis)
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.l Cardiac- cardiorespiratory/pulmonary arrest
X. Pulmonary edema
X.b Pulmonary edema, noncardiogenic (NCPE)
X. Pulmonary edema
X.g Flash (fulminate) pulmonary edema
X. Pulmonary edema
X.h Negative pressure pulmonary edema (NPPE)
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXIII. Hemoglobinopathies (acquired, reversible)
XXIII.a Methemoglobinemia
XXVIII. Large airway involvement
XXVIII.a Angioedema (may cause UAO, asphyxia and death)
XXVIII. Large airway involvement
XXVIII.q Central airway instability - Tracheomalacia
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXIX. Small airway involvement
XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVIII. Miscellaneous - Varia
XXXVIII.d Death following exposure or poisoning
XXXVIII. Miscellaneous - Varia
XXXVIII.f Cyanosis, a low SpO2 and normal measured PaO2
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.j Asystole
X. Pulmonary edema
X.b Pulmonary edema, noncardiogenic (NCPE)
XIII. Thrombosis - Embolism
XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism
XIII. Thrombosis - Embolism
XIII.f Fat/oil embolism - The FES embolism syndrome
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV. Pleural involvement
XIV.f Pneumothorax
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)
XXXIII.o Path: Lipid/fat embolism
XXXVIII. Miscellaneous - Varia
XXXVIII.h Hypoxemia, low oxygen saturation (may occur in isolation)
XIV. Pleural involvement
XIV.d Eosinophilic pleural effusion
XIX. Angioedema
XIX.b Visceral angioedema
XXVIII. Large airway involvement
XXVIII.a Angioedema (may cause UAO, asphyxia and death)
XXVIII. Large airway involvement
XXVIII.f Laryngospasm (a.k.a. laryngismus)
XXVIII. Large airway involvement
XXVIII.i Tongue involvement (edema, glossitis, hematoma)
XXIX. Small airway involvement
XXIX.d Cough (lone)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.b Lupus - Lupus syndrome
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.k Sinus arrest
IV. Heart block (bundle branch-, AV-block)
IV.a Heart block (bundle branch- or AV-)
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXXVIII. Miscellaneous - Varia
XXXVIII.a Upper airway obstruction other than angioedema or hematoma
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.e Bradycardia
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.g QTc prolongation
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.i Torsades de pointe
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.l Cardiac- cardiorespiratory/pulmonary arrest
IV. Heart block (bundle branch-, AV-block)
IV.a Heart block (bundle branch- or AV-)
VI. Cardiomyopathy
VI.c Takotsubo (stress) cardiomyopathy
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
XXII. Acute respiratory/cardiorespiratory failure
XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVIII. Miscellaneous - Varia
XXXVIII.d Death following exposure or poisoning
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.x Radiation-induced lung injury (RILI)
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.j Asystole
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
III. Myocardial ischemia - Coronary artery disease
III.c Coronary vasospasm - Vasospastic angina
III. Myocardial ischemia - Coronary artery disease
III.e Coronary artery dissection
IV. Heart block (bundle branch-, AV-block)
IV.a Heart block (bundle branch- or AV-)
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV. Pleural involvement
XIV.f Pneumothorax
XIV. Pleural involvement
XIV.l Pneumothorax, bilateral
XV. Chest pain
XV.a Chest pain (acute or subacute), lone or prominent
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.i Hemoptysis
XXI. Mediastinal involvement/injury
XXI.c Pneumomediastinum
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXII. Acute respiratory/cardiorespiratory failure
XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.d Acute eosinophilic pneumonia (AEP)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.k Pulmonary infiltrates
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.y Exogenous lipoid pneumonia (subacute, acute)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.ad Pulmonary alveolar proteinosis (PAP)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.ae Pneumoconiosis (silicosis, talcosis...)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.af Hypersensitivity pneumonitis pattern
XXIX. Small airway involvement
XXIX.d Cough (lone)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVIII. Miscellaneous - Varia
XXXVIII.e Sniffing death - Death from inhalation of compound
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.d Acute eosinophilic pneumonia (AEP)