The Drug-Induced Respiratory Disease Website

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XI. Pulmonary vasculopathies

XI.c Rebound pulmonary arterial hypertension

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

XXXVIII. Miscellaneous - Varia

XXXVIII.h Hypoxemia, low oxygen saturation (may occur in isolation)

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.n Respiratory arrest - Apnea

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XII. Pericardial involvement

XII.g Pleural/pericardial effusion, ANA positive (DI lupus)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.d Eosinophilic pleural effusion

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XV. Chest pain

XV.b Pleuritic chest pain

XV. Chest pain

XV.e Pleuritis (can cause chest pain)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.c Hematoma of/around central airway wall potentially causing UAO

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXI. Mediastinal involvement/injury

XXI.a Lymphadenopathy (intrathoracic)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.f Diffuse alveolar damage (DAD) imaging pattern

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ab Chronic pneumonitis/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ah Transient pulmonary opacities/infiltrates (see also under Iav)

XXV. Pulmonary function - Pulmonary physiology - PFTs

XXV.i A restrictive lung function defect

XXVIII. Large airway involvement

XXVIII.o A ‘tracheobronchitis’ clinical pattern

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXX. Imaging features

XXX.u Imaging: Reverse ventilation-perfusion mismatch

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.a Autoimmunity - An autoimmune condition (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b Lupus - Lupus syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.u Pulmonary vasculitis or capillaritis

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XII. Pericardial involvement

XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXVIII. Large airway involvement

XXVIII.k Rhinosinusitis

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.e Obliterative bronchiolitis (an imaging and/or pathological pattern consistent with)

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXIX. Small airway involvement

XXIX.l Bronchiolitis (a clinical-imaging pattern suggestive of)

XXXII. Esophageal pathology

XXXII.e Esophageal toxicity

XXXII. Esophageal pathology

XXXII.j Esophageal necrosis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.q Tumor lysis syndrome (TLS)

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)