The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.n Respiratory arrest - Apnea

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

X. Pulmonary edema

X.e Overload pulmonary edema (including posttransfusional (TACO))

XXXVIII. Miscellaneous - Varia

XXXVIII.m Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XI. Pulmonary vasculopathies

XI.f Worsening of preexisting PHTn

XII. Pericardial involvement

XII.g Pleural/pericardial effusion, ANA positive (DI lupus)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.h Pleural thickening - Fibrothorax

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.e Relapsing or migrating pneumonitis/pneumonia (see also Id)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXIX. Small airway involvement

XXIX.h Exacerbation or deterioration of preexisting asthma

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b Lupus - Lupus syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.d Subclinical ANA positivity

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.l Refractoriness to epineprine in case of anaphylaxis

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

XII. Pericardial involvement

XII.g Pleural/pericardial effusion, ANA positive (DI lupus)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIII. Thrombosis - Embolism

XIII.o Systemic arterial thrombosis

XIV. Pleural involvement

XIV.k Esophageal pleural fistula

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.j Major/massive hemoptysis

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.o Epistaxis

XVIII. Aortic involvement

XVIII.d Aortitis

XX. Vasculitis

XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

XXII. Acute respiratory/cardiorespiratory failure

XXII.c Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

XII. Pericardial involvement

XII.a Pericarditis