The Drug-Induced Respiratory Disease Website

XIV. Pleural involvement

XIV.f Pneumothorax

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.b Pulmonary hematoma

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.f Alveolar hemorrhage, localized (e.g. lobar)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.j Major/massive hemoptysis

XXX. Imaging features

XXX.g Imaging: Pneumatocele or pneumatoceles

XXX. Imaging features

XXX.i Imaging: Cavitating/cavitary lung/pulmonary nodule or nodules

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.s ILD with a granulomatous component

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.x Granulomatous mediastinal lymphadenopathy

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.c Sarcoid-like granulomatosis (endo-/extrathoracic)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.aa Granulomatosis with polyangiitis (typically +ANCA). Or flare of preexisting GPA

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.k Multiple organ dysfunction/failure (MODS/MOF)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.f Cyanosis, a low SpO2 and normal measured PaO2

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.p An area or areas of consolidation

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.r Lung nodule or nodules

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXX. Imaging features

XXX.e Imaging: An area or areas of consolidation

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXIX. Rechallenge

XXXIX.e Rechallenge may not lead to relapse of the AE/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XX. Vasculitis

XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXVII. Dyspnea, lone

XXVII.a Dyspnea, unexplained otherwise

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXXVIII. Miscellaneous - Varia

XXXVIII.u Hypocalcemia (may lead to respiratory muscle weakness and RF)

XXXVIII. Miscellaneous - Varia

XXXVIII.v Osteonecrosis of the jaw

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma