The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

X. Pulmonary edema

X.g Flash (fulminate) pulmonary edema

X. Pulmonary edema

X.h Negative pressure pulmonary edema (NPPE)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXVIII. Large airway involvement

XXVIII.q Central airway instability - Tracheomalacia

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

XXXVIII. Miscellaneous - Varia

XXXVIII.f Cyanosis, a low SpO2 and normal measured PaO2

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.i Torsades de pointe

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.m Subclinical pulmonary infiltrates/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.u Transient pulmonary opacities/infiltrates (TAPO)

XXXIX. Rechallenge

XXXIX.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

XXXIX. Rechallenge

XXXIX.e Rechallenge may not lead to relapse of the AE/ILD

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.h Myasthenia gravis - Myasthenic-like syndrome

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.f Capillary leak syndrome (CLS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.i Guillain-Barré (or GB-like) syndrome (w/wo ARF)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.ac Antisynthetase antibodies (ASA) - ASA syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.k Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

XII. Pericardial involvement

XII.g Pleural/pericardial effusion, ANA positive (DI lupus)

XII. Pericardial involvement

XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.d Eosinophilic pleural effusion

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXVIII. Large airway involvement

XXVIII.i Tongue involvement (edema, glossitis, hematoma)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning