The Drug-Induced Respiratory Disease Website

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

X. Pulmonary edema

X.d Fluid retention

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.f Tachycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

III. Myocardial ischemia - Coronary artery disease

III.g ST segment changes

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

X. Pulmonary edema

X.c Interstitial pulmonary edema

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.y Cytokine release syndrome

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.j Major/massive hemoptysis

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXXIX. Rechallenge

XXXIX.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

V. Myocarditis

V.b Eosinophilic myocarditis

V. Myocarditis

V.f Myopericarditis

V. Myocarditis

V.h Relapse of previously diagnosed myocarditis

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XI. Pulmonary vasculopathies

XI.j Pulmonary infarction

XII. Pericardial involvement

XII.a Pericarditis

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XII. Pericardial involvement

XII.e Constrictive pericarditis - Pericardial thickening

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XX. Vasculitis

XX.c Vascultis (pulmonary, extrathoracic or systemic) - ANCA status unknown or negative

XX. Vasculitis

XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.v Radiation recall pneumonitis

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.h Exacerbation or deterioration of preexisting asthma

XXX. Imaging features

XXX.l Imaging: Ground-glass opacities / GGO shadowing

XXX. Imaging features

XXX.p Imaging: Asymmetrical, predominantly unilateral involvement

XXX. Imaging features

XXX.s Imaging: A mosaic pattern of attenuation

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b Lupus - Lupus syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.i Guillain-Barré (or GB-like) syndrome (w/wo ARF)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.j Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.n A flare of preexisting immune-mediated systemic/rheumatic disease

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.x Anti Jo1 syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.z Protracted, prolonged anaphylaxis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.ae Polyarteritis nodosa-like condition

XXXVIII. Miscellaneous - Varia

XXXVIII.c Antiphospholipid antibodies w/wo the APL syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.q Myopathy-Myositis-Polymyositis

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

VII. Cardiotoxicity

VII.b Veterinary: Cardiotoxicity

IX. Endocardial involvement

IX.b Endocardial fibroelastosis