The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIII. Thrombosis - Embolism

XIII.o Systemic arterial thrombosis

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.w Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.k Multiple organ dysfunction/failure (MODS/MOF)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

XXXVIII. Miscellaneous - Varia

XXXVIII.r Hyperemesis

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.b Atrial fibrillation

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VIII. Valvular heart disease

VIII.a Valvular heart disease and/or dysfunction

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XI. Pulmonary vasculopathies

XI.i Pulmonary veno-occlusive disease

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XXVI. Neuromuscular dysfunction

XXVI.a Phrenic nerve injury - Hemi- or bilateral diaphragmatic paralysis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.k Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

III. Myocardial ischemia - Coronary artery disease

III.e Coronary artery dissection

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XII. Pericardial involvement

XII.k Pneumopericardium

XIII. Thrombosis - Embolism

XIII.o Systemic arterial thrombosis

XVIII. Aortic involvement

XVIII.b Aortic dissection

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VI. Cardiomyopathy

VI.b Hypertrophic cardiomyopathy

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

XIV. Pleural involvement

XIV.j Black pleural effusion

XVIII. Aortic involvement

XVIII.c Arterial (aorta, limb) vasoconstriction and/or ischemia, acute

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.f Pneumothorax

XV. Chest pain

XV.d Chest tightness

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.m BAL: Gross or microscopic bleeding/hemorrhage

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.c Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

XXIII. Hemoglobinopathies (acquired, reversible)

XXIII.a Methemoglobinemia

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXVII. Dyspnea, lone

XXVII.a Dyspnea, unexplained otherwise

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXIX. Small airway involvement

XXIX.f Deterioration/exacerbation of preexisting asthma or COPD

XXX. Imaging features

XXX.e Imaging: An area or areas of consolidation

XXX. Imaging features

XXX.f Imaging: Alveolar opacities or haze with a batwing or butterfly distribution

XXX. Imaging features

XXX.l Imaging: Ground-glass opacities / GGO shadowing

XXXI. Eye catchers

XXXI.e Eye catcher: A batwing or butterfly pattern on chest imaging

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.k Path: Alveolar hemorrhage

XXXIV. Infections

XXXIV.b Respiratory tract infection incl. pneumonia

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.p Multisystem/systemic inflammatory response/syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.c Antiphospholipid antibodies w/wo the APL syndrome

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.f Tachycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.j Asystole

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

V. Myocarditis

V.b Eosinophilic myocarditis

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

VII. Cardiotoxicity

VII.b Veterinary: Cardiotoxicity

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.m Sudden cardiac death

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

V. Myocarditis

V.e Necrotizing myocarditis (w/o evidence for CAD)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.i Serositis - Polyserositis

XV. Chest pain

XV.e Pleuritis (can cause chest pain)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XXI. Mediastinal involvement/injury

XXI.a Lymphadenopathy (intrathoracic)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.e Relapsing or migrating pneumonitis/pneumonia (see also Id)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.l Acute fibrinous organizing pneumonia (AFOP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.o Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.q Delayed ILD, -pneumonitis, -fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.v Radiation recall pneumonitis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ab Chronic pneumonitis/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ac Shrinking lung syndrome

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXX. Imaging features

XXX.h Imaging: Avid pleural uptake on PET-scan

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.f Path: Myocardial vasculitis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.q Tumor lysis syndrome (TLS)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.v Temporal arteritis (Horton’s)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXVIII. Large airway involvement

XXVIII.a Angioedema (may cause UAO, asphyxia and death)

XXXVIII. Miscellaneous - Varia

XXXVIII.e Sniffing death - Death from inhalation of compound