Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXIX.a

XXIX - Small airway involvement

Bronchospasm - Wheezing - Asthma

Last update 17/06/2026

(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)

Causative drugs

51
Food - Food products - Food additives
X.a
XXII.b
XXIII.a
XXIX.a
XXIX.c
XXX.o
XXXVI.c
XXXVI.f
Hydralazine
XII.b
XII.e
XII.g
XII.n
XV.e
XVI.e
XVI.g
XX.c
XX.d
XXII.b
XXIV.a
XXIV.b
XXIV.j
XXVIII.a
XXVIII.d
XXIX.a
XXIX.b
XXXVI.a
XXXVI.b
XXXVI.m
XXXVI.s
XXXVI.t
XXXVI.u
XXXVIII.a
Hydroxychloroquine
I.a
I.g
I.i
II.a
IV.a
VI.a
XI.a
XXIX.a
XXXIII.e
Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx
I.a
I.m
II.a
II.c
II.d
III.a
IV.a
V.a
V.e
VI.c
VII.a
X.a
XI.a
XII.b
XIII.a
XIV.a
XIV.i
XV.e
XVI.h
XXI.a
XXII.b
XXIV.a
XXIV.b
XXIV.c
XXIV.d
XXIV.e
XXIV.h
XXIV.i
XXIV.j
XXIV.l
XXIV.o
XXIV.q
XXIV.v
XXIV.ab
XXIV.ac
XXIX.a
XXIX.i
XXX.h
XXXIII.f
XXXVI.f
XXXVI.q
XXXVI.v
Infliximab
V.a
XII.a
XII.g
XIII.a
XIII.n
XIV.a
XVI.e
XXII.b
XXIV.a
XXIV.b
XXIV.c
XXIV.d
XXIV.h
XXIV.i
XXIV.j
XXIV.o
XXIX.a
XXX.l
XXXVI.a
XXXVI.b
XXXVI.u
XXXVIII.c
Lidocaine (lignocaine, xylocaine)
I.a
I.l
X.b
X.g
X.h
XXII.b
XXIII.a
XXVIII.a
XXVIII.q
XXIX.a
XXIX.c
XXXVI.f
XXXVIII.d
XXXVIII.f
Methamphetamine
I.m
II.e
III.a
VI.a
X.b
XI.a
XV.a
XVI.e
XX.c
XXII.b
XXIV.b
XXIX.a
XXXVI.k
XXXVIII.d
XXXVIII.s
Naproxen
X.b
XXIV.c
XXIX.a
XXXVI.f
XXXVI.m
Nitrofurantoin
I.n
X.b
XII.g
XIV.a
XIV.d
XV.a
XV.b
XV.e
XVI.c
XVI.e
XXI.a
XXII.b
XXIV.a
XXIV.b
XXIV.c
XXIV.d
XXIV.f
XXIV.h
XXIV.j
XXIV.ab
XXIV.ah
XXV.i
XXVIII.o
XXIX.a
XXX.u
XXXVI.a
XXXVI.b
XXXVI.f
XXXVI.m
XXXVI.u
Nivolumab
II.d
III.a
IV.a
V.a
VII.a
X.a
XII.b
XII.n
XXII.b
XXVIII.k
XXIX.a
XXIX.e
XXIX.i
XXIX.l
XXXII.e
XXXII.j
XXXVI.m
XXXVI.q
Oxytocin
II.a
X.b
XXVIII.a
XXIX.a
XXIX.j
XXXVI.f
Pembrolizumab
II.c
IV.a
V.a
XI.a
XII.b
XII.n
XIII.a
XXIV.a
XXIV.b
XXVIII.i
XXIX.a
XXIX.i
XXXIII.a
XXXIII.f
XXXVI.f
XXXVI.h
XXXVI.v
XXXVI.ad
Proton pump inhibitors
XXVIII.a
XXIX.a
XXIX.i
XXXIV.b
XXXVI.f
XXXVIII.k
Radiocontrast media (RCM)
I.e
X.b
XXIX.a
XXIX.k
Rifampicin
XIII.a
XXII.b
XXIV.a
XXIV.b
XXIV.c
XXIX.a
XXXVI.k